Head Loss Reduction in Surcharged Four-Way Junction Manholes

Alternative conformations of a nucleic acid four-way junction.

A crystal structure of a 108 nucleotide RNA-DNA complex containing a four-way junction was solved at 3.1 A resolution. The structure of the junction differs substantially from the "stacked-X" conformation observed previously, due to a 135 degrees rotation of the branches. Comparison of the two conformers provides insight into the factors contributing to the flexibility of four-way junctions. Th...

Report Cards for Manholes

We present a manhole profiling tool, developed as part of the Columbia/Con Edison machine learning project on manhole event prediction, and discuss its role in evaluating our machine learning model in three important ways: elimination of outliers, elimination of falsely predictive features, and assessment of the quality of the model. The model produces a ranked list of tens of thousands of manh...

Molecular modeling and structural studies of 12-mer immobile four-way DNA junction in solution

Molecular modelling and structural studies of 12-mer immobile four-way DNA junction model is reported here. The DNA junction which was built and investigated, consisted of the following sequences 5'd(GGAAGGGGCTGG), 5'd(CCAGCCTGAGCC), 5'd(GGCTCAACTCGG) and 5'd(CCGAGTCCTTCC). The model was made in such a way that the junction may lack two-fold sequence symmetry at the crossover point. A new versi...

Four-junction superconducting circuit

We develop a theory for the quantum circuit consisting of a superconducting loop interrupted by four Josephson junctions and pierced by a magnetic flux (either static or time-dependent). In addition to the similarity with the typical three-junction flux qubit in the double-well regime, we demonstrate the difference of the four-junction circuit from its three-junction analogue, including its adv...

Binding Parameters of Integration Host Factor to Four-Way Holliday Junction DNA